Geometry Selects Highly Designable Structures

Дата и время публикации : 2000-09-18T10:00:06Z

Авторы публикации и институты :
V. Shahrezaei
M. R. Ejtehadi

Ссылка на журнал-издание: J. Chem. Phys. 113, 6437 (2000)
Коментарии к cтатье: 6 figure, To be appear in JCP
Первичная категория: cond-mat.soft

Все категории : cond-mat.soft, q-bio

Краткий обзор статьи: By enumerating all sequences of length 20, we study the designability of structures in a two-dimensional Hydrophobic-Polar (HP) lattice model in a wide range of inter-monomer interaction parameters. We find that although the histogram of designability depends on interaction parameters, the set of highly designable structures is invariant. So in the HP lattice model the High Designability should be a purely geometrical feature. Our results suggest two geometrical properties for highly designable structures, they have maximum number of contacts and unique neighborhood vector representation. Also we show that contribution of perfectly stable sequences in designability of structures plays a major role to make them highly designable.

Category: Physics