Mean-Field HP Model, Designability and Alpha-Helices in Protein Structures

Дата и время публикации : 1998-12-15T01:20:56Z

Авторы публикации и институты :
C. T. Shih
Z. Y. Su
J. F. Gwan
H. C. Lee
B. L. Hao
C. H. Hsieh

Ссылка на журнал-издание: Phys. Rev. Lett. 84, p.386, 2000
Коментарии к cтатье: 4 pages, 2 figures
Первичная категория: cond-mat.soft

Все категории : cond-mat.soft, q-bio

Краткий обзор статьи: Analysis of the geometric properties of a mean-field HP model on a square lattice for protein structure shows that structures with large number of switch backs between surface and core sites are chosen favorably by peptides as unique ground states. Global comparison of model (binary) peptide sequences with concatenated (binary) protein sequences listed in the Protein Data Bank and the Dali Domain Dictionary indicates that the highest correlation occurs between model peptides choosing the favored structures and those portions of protein sequences containing alpha-helices.

Category: Physics