Stability Threshold as a Selection Principle for Protein Design

Дата и время публикации : 1997-04-20T08:58:07Z

Авторы публикации и институты :
Michele Vendruscolo
Amos Maritan
Jayanth R. Banavar

Ссылка на журнал-издание: Ссылка на журнал-издание не найдена
Коментарии к cтатье: 4 pages, RevTex, 4 figures included, to appear on Phys. Rev. Lett
Первичная категория: cond-mat.soft

Все категории : cond-mat.soft, q-bio

Краткий обзор статьи: The sensitivity of the native states of protein-like heteropolymers to mutations modelled as perturbations in the interaction potential between amino acids is studied. The stability threshold against mutations is shown to be zero for random heteropolymers on a lattice in two dimensions, whereas a design procedure modelling evolution produces a non-zero threshold. We introduce an evolution-like protein design procedure based on an optimization of the stability threshold that is shown to naturally ensure thermodynamic stability as well.

Category: Physics